Fractional Gaussian noise (FGN) with the Hurst exponent $H$ is an important tool to model various phenomena in biophysical systems, like subdiffusion in a single protein molecule. Considering that there also exists a confined structure which can be modeled as a channel in these systems, transport and escape driven by FGN in a deformable channel are investigated in this paper. By calculating the mean velocity, and the mean first passage time (MFPT) for crossing the nearest bottleneck and the probability distribution of the final position, effects of FGN and channel structure on the system dynamics are illustrated. Our results indicate that FGN has a complex influence mechanism under different combinations of $H$ and the noise intensity. For a persistence case $(H>0.5)$, the mean velocity decreases but MFPT increases with the increase of the noise intensity and $H$. While for an antipersistence case $(H<0.5)$, when $H$ is small, the relationships among the mean velocity, MFPT and the noise intensity are exactly the opposite to persistence cases. When $H$ has a large value, the mean velocity tends to first decrease and then increase. Moreover, effects of the bottleneck and channel asymmetry are investigated. It is shown that a small $H$ and a large channel width can lead to a large mean velocity and fast crossing. Besides, a channel asymmetry can affect the system dynamics by inducing asymmetric structure and adjusting the width of bottleneck. However, the effect of the bottleneck is the main factor. Therefore, a combination of channel with wide bottleneck and FGN in an antipersistence regime is the optimal choice to promote the transport and escape. These results provide a basis for the explanation of molecular activity in living organisms and the design of particle mixture separators.

• Received 20 February 2019
• Revised 26 June 2019

DOI:https://doi.org/10.1103/PhysRevE.100.022114