Pulse requirements for x-ray diffraction imaging of single biological molecules

Stefan P. Hau-Riege, Richard A. London, Gosta Huldt, and Henry N. Chapman

Phys. Rev. E 71, 061919 – Published 28 June 2005

Abstract

In this paper we estimate the required pulse parameters for the future application of x-ray free electron lasers to imaging single biological molecules. The parameters are determined by a tradeoff between minimizing image degradation due to damage and maximizing the image signal-to-noise ratio. We discuss several means to alleviate the pulse requirements, and compare the requirements with parameters of two planned x-ray lasers.

Received 10 January 2005

DOI:https://doi.org/10.1103/PhysRevE.71.061919

Authors & Affiliations

Stefan P. Hau-Riege¹, Richard A. London¹, Gosta Huldt², and Henry N. Chapman¹

¹Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551, USA
²Biomedical Center, Uppsala University, Box 576, SE 75123, Uppsala, Sweden

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Vol. 71, Iss. 6 — June 2005

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Physical Review E

covering statistical, nonlinear, biological, and soft matter physics