Recombination in the Avian Oncoviruses as a Model for the Generation of Defective Transforming Viruses
This extract was created in the absence of an abstract.
Excerpt
One of the unique aspects of oncoviral multiplication is the occurrence of relatively high-frequency genetic recombination (Vogt 1970; Kawai and Hanafusa 1972; Wyke et al. 1975; Blair 1977). For example, in crosses involving two sarcoma viruses, no significant linkage could be detected among markers in the gag, pol, env, and src genes or even between markers within the gag gene (Linial and Brown 1979), suggesting that recombinational events may frequently occur throughout the genome.
At present, little is known concerning the detailed nature of the molecular events involved in recombination. It has been postulated that recombination occurs prior to proviral integration, possibly during reverse transcription (Cooper and Wyke 1975; Coffin 1979) or among completed, or partially complete, proviral DNA molecules (Hunter 1978). One clue comes from the observation that heterozygous or genetically mixed particles arise after one cycle of mixed infection, followed by the appearance of true recombinants upon reinfection...
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↵* Present address: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.
