Pretrial hippocampal θ-state differentiates single-unit response profiles during rabbit trace eyeblink conditioning
- 1Department of Psychology and Center for Neuroscience, Miami University, Oxford, Ohio 45056, USA
- 2Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
- Corresponding author: berrysd{at}miamioh.edu
Abstract
Eyeblink conditioning given in the explicit presence of hippocampal θ results in accelerated learning and enhanced multiple-unit responses, with slower learning and suppression of unit activity under non-θ conditions. Recordings from putative pyramidal cells during θ-contingent training show that pretrial θ-state is linked to the probability of firing increases versus decreases rather than to the magnitude of such responses. These findings suggest that the learning facilitation during θ may be due to the recruitment of additional neurons that increase their firing rate during trials.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.038216.115.
- Received January 18, 2015.
- Accepted April 23, 2015.
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