Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence
- Aline Werenicz1,2,3,
- Raissa R. Christoff1,2,3,
- Martina Blank1,2,3,
- Paulo F.C. Jobim1,2,3,
- Thiago R. Pedroso1,2,3,
- Gustavo K. Reolon1,2,3,
- Nadja Schröder3,4 and
- Rafael Roesler1,2,3,5
- 1Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil
- 2Cancer Research Laboratory, University Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, Brazil
- 3National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil
- 4Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, 90619-900 Porto Alegre, RS, Brazil
Abstract
Here we show that administration of the phosphodiesterase type 4 (PDE4) inhibitor rolipram into the basolateral complex of the amygdala (BLA) at a specific time interval after training enhances memory consolidation and induces memory persistence for novel object recognition (NOR) in rats. Intra-BLA infusion of rolipram immediately, 1.5 h, or 6 h after training had no effect on retention tested at 1, 7, and 14 d later. However, rolipram infused 3 h post-training promoted memory persistence for up to at least 14 d. The findings suggest that PDE4 inhibition in the BLA can enhance long-term memory formation when induced specifically 3 h after learning.
Footnotes
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↵5 Corresponding author
E-mail rafael.roesler{at}pq.cnpq.br
- Received May 8, 2012.
- Accepted May 30, 2012.
- © 2012 Cold Spring Harbor Laboratory Press
