A small RNA serving both the Hfq and CsrA regulons
Abstract
The abundant RNA-binding proteins CsrA and Hfq each impact bacterial physiology by working in conjunction with small RNAs to control large post-transcriptional regulons. The small RNAs involved were considered mechanistically distinct, regulating mRNAs either directly through Hfq-mediated base-pairing or indirectly by sequestering the global translational repressor CsrA. In this issue of Genes & Development, Jørgensen and colleagues (pp. 1132–1145) blur these distinctions with a dual-mechanism small RNA that acts through both Hfq and CsrA to regulate the formation of bacterial biofilms.
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↵1 Corresponding author
E-mail joerg.vogel{at}uni-wuerzburg.de
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.220178.113.
- Copyright © 2013 by Cold Spring Harbor Laboratory Press
