Murine-leukemia-virus-related Cell-surface Antigens as Serological Markers of AKR Ecotropic, Xenotropic, and Dualtropic Viruses
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Excerpt
Several systems of cell-surface antigens related to naturally occurring murine leukemia virus (MuLV) have been recognized serologically (Table 1). These antigens are defined by the conventional cytotoxic test (Old and Stockert 1978). Gross cell-surface antigen (GCSA) (Old et al. 1965) was recognized by sera of mice hyperimmunized with a spontaneous leukemia of the AKR strain; Gix antigen (Stockert et al. 1971) was recognized by sera of rats bearing transplants of a syngeneic leukemia induced originally by MuLV. More recently, cell-surface antigens G(RADA1) (Obata et al. 1978), G(ERLD) (Y. Obata et al., in prep.), and G(AKSL2) (Stockert et al. 1979) have been defined by normal mouse serum of selected F1 hybrids. Expression of antigen on other cells is determined by absorption of the typing antiserum followed by assay of residual cytotoxicity on the prototype target cell (see Table 1).
GCSA has been shown to consist of both type-specific and group-specific antigenic...
