Mutation and Recombination at the Host Range Genetic Region of Phage T21
This extract was created in the absence of an abstract.
Excerpt
Studies of the genetic fine structure of a functional unit occupying a short region in phage can be expected to yield manifold information concerning the nature of mutation and recombination. Specifically, the size of mutated sites and the distances between mutated sites can be described in terms of recombination frequency, and an attempt can be made to translate them into molecular terms. By comparing the site of back mutations to the site of the original mutation, information may be gained concerning the potential configurations that give rise to a functional product. The ability of a genetic region to produce a functional product can, in addition, be investigated by comparing the function of genetic information at a given region when present in “cis” versus “trans” arrangements. If the product of a region can be identified and isolated, it should be possible to compare the information carried by the genetic material with...
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↵2 Fellow of the National Foundation for Infantile Paralysis; present address: Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor, N. Y.
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↵3 Postdoctoral Public Health Service Research Fellow of The National Cancer Institute; present address: Max-Planck-Institut für Biologie, Tübingen, Germany.
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↵1 Aided by a grant from the National Foundation for Infantile Paralysis.
