Cooperative regulation in development by SMRT and FOXP1
- 1 Department of Medicine, Howard Hughes Medical Institute, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA;
- 2 Cleveland Biolabs, Inc., Buffalo, New York 14052, USA;
- 3 University Hospitals Case Medical Center, Case Western Reserve University School of Medicine. Cleveland, Ohio 44106, USA
Abstract
A critical aspect of mammalian development involves the actions of dedicated repressors/corepressors to prevent unregulated gene activation programs that would initiate specific cell determination events. While the role of NCoR/SMRT corepressors in nuclear receptor actions is well documented, we here report that a previously unrecognized functional interaction between SMRT and a forkhead protein, FOXP1, is required for cardiac growth and regulation of macrophage differentiation. Our studies demonstrate that SMRT and FOXP1 define a functional biological unit required to orchestrate specific programs critical for mammalian organogenesis, linking developmental roles of FOX to a specific corepressor.
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Footnotes
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↵4 Corresponding authors.
↵4 E-MAIL mrosenfeld{at}ucsd.edu; FAX (858) 534-8180.
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↵5 E-MAIL jepsen{at}ucsd.edu; FAX (858) 534-8180.
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Supplemental material is available at http://www.genesdev.org.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1637108.
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- Received November 27, 2007.
- Accepted January 18, 2008.
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Freely available online through the Genes & Development Open Access option.
- Copyright © 2008, Cold Spring Harbor Laboratory Press
