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Genomics of Egyptian Healthy Volunteers: The EHVol Study
View ORCID ProfileYasmine Aguib, View ORCID ProfileMona Allouba, Alaa Afify, Sarah Halawa, Mohamed ElKhateb, Marina Sous, Aya Galal, Eslam Abdelrahman, Nairouz Shehata, Amr El Sawy, Mohamed Maghawry, Shehab Anwer, Omnia Kamel, Wessam El-Mozy, Hadir Khedr, Ahmed Essam, Nagwa Thabet, Pantazis Theotokis, Rachel Buchan, Risha Govind, View ORCID ProfileNicola Whiffin, Roddy Walsh, Heba Aguib, Ahmed Elguindy, Stuart A Cook, Paul J Barton, James Ware, Magdi Yacoub
doi: https://doi.org/10.1101/680520
Yasmine Aguib
1Aswan Heart Centre, Aswan, Egypt
2National Heart and Lung Institute, Imperial College London, London, UK
Mona Allouba
1Aswan Heart Centre, Aswan, Egypt
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
Alaa Afify
1Aswan Heart Centre, Aswan, Egypt
Sarah Halawa
1Aswan Heart Centre, Aswan, Egypt
4The American University in Cairo, AUC Ave, Cairo, Egypt
Mohamed ElKhateb
1Aswan Heart Centre, Aswan, Egypt
Marina Sous
1Aswan Heart Centre, Aswan, Egypt
Aya Galal
1Aswan Heart Centre, Aswan, Egypt
Eslam Abdelrahman
1Aswan Heart Centre, Aswan, Egypt
Nairouz Shehata
1Aswan Heart Centre, Aswan, Egypt
Amr El Sawy
1Aswan Heart Centre, Aswan, Egypt
Mohamed Maghawry
1Aswan Heart Centre, Aswan, Egypt
Shehab Anwer
1Aswan Heart Centre, Aswan, Egypt
Omnia Kamel
1Aswan Heart Centre, Aswan, Egypt
Wessam El-Mozy
1Aswan Heart Centre, Aswan, Egypt
Hadir Khedr
1Aswan Heart Centre, Aswan, Egypt
Ahmed Essam
1Aswan Heart Centre, Aswan, Egypt
Nagwa Thabet
1Aswan Heart Centre, Aswan, Egypt
Pantazis Theotokis
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
Rachel Buchan
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
Risha Govind
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
Nicola Whiffin
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
8MRC London Institute of Medical Sciences, Imperial College London, London, UK
Roddy Walsh
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
7Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Amsterdam, Netherlands
Heba Aguib
1Aswan Heart Centre, Aswan, Egypt
Ahmed Elguindy
1Aswan Heart Centre, Aswan, Egypt
2National Heart and Lung Institute, Imperial College London, London, UK
Stuart A Cook
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
5National Heart Centre Singapore, Singapore, Singapore
6Duke-National University of Singapore, Singapore, Singapore
Paul J Barton
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
James Ware
2National Heart and Lung Institute, Imperial College London, London, UK
3Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK
8MRC London Institute of Medical Sciences, Imperial College London, London, UK
Magdi Yacoub
1Aswan Heart Centre, Aswan, Egypt
2National Heart and Lung Institute, Imperial College London, London, UK
9Harefield Heart Science Centre, Harefield, Middlesex, United Kingdom
ABSTRACT
Comprehensive genomic databases offer unprecedented opportunities towards effective tailored strategies for the prevention and treatment of disease. The integration of genomic and phenotypic data from diverse ethnic populations is also key to advancements in precision medicine and novel diagnostic technologies. Current reference genomic databases, however, are not representative of the global human population, making variant interpretation challenging and uncertain, especially in underrepresented populations such as the North African population. To address this, a study of 391 Egyptian healthy volunteers (EHVols) was initiated as a milestone towards establishing the 1000 Egyptian Genomes project.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted June 23, 2019.
Genomics of Egyptian Healthy Volunteers: The EHVol Study
Yasmine Aguib, Mona Allouba, Alaa Afify, Sarah Halawa, Mohamed ElKhateb, Marina Sous, Aya Galal, Eslam Abdelrahman, Nairouz Shehata, Amr El Sawy, Mohamed Maghawry, Shehab Anwer, Omnia Kamel, Wessam El-Mozy, Hadir Khedr, Ahmed Essam, Nagwa Thabet, Pantazis Theotokis, Rachel Buchan, Risha Govind, Nicola Whiffin, Roddy Walsh, Heba Aguib, Ahmed Elguindy, Stuart A Cook, Paul J Barton, James Ware, Magdi Yacoub
bioRxiv 680520; doi: https://doi.org/10.1101/680520
Genomics of Egyptian Healthy Volunteers: The EHVol Study
Yasmine Aguib, Mona Allouba, Alaa Afify, Sarah Halawa, Mohamed ElKhateb, Marina Sous, Aya Galal, Eslam Abdelrahman, Nairouz Shehata, Amr El Sawy, Mohamed Maghawry, Shehab Anwer, Omnia Kamel, Wessam El-Mozy, Hadir Khedr, Ahmed Essam, Nagwa Thabet, Pantazis Theotokis, Rachel Buchan, Risha Govind, Nicola Whiffin, Roddy Walsh, Heba Aguib, Ahmed Elguindy, Stuart A Cook, Paul J Barton, James Ware, Magdi Yacoub
bioRxiv 680520; doi: https://doi.org/10.1101/680520
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