Direct Detection and Identification of Viruses in Saliva Using a SpecID™ Ionization Modified Mass Spectrometer

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This research was supported in its entirety by the U.S. Food and Drug Administration.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Having obtained FDA IRB approval, the saliva used in this study was collected from consenting healthy human volunteers and used to prepare the various viral suspensions analyzed. Volunteers at our facility, who agreed to participate in our study, provided saliva in 1.5 mL microcentrifuge tubes at least 60 min after the most recently ingested meal. The volunteers have provided us with a signed hard-copy consent form, which we have a copy of.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes