How Does RNA Editing Affect dsRNA-mediated Gene Silencing?

Abstract

In general, double-stranded RNA (dsRNA)-binding proteins (dsRBPs) are not sequence-specific. A dsRNA molecule in a cellwill interact with any dsRBP it comes in contact with, suggesting that different dsRNA-mediated pathways intersect and affecteach other. This paper analyzes evidence that the ADAR RNA editing enzymes, which act on dsRNA, affect dsRNA-mediatedgene silencing pathways. Examples of how ADARs alter gene silencing pathways such as RNA interference, as well asmechanisms that allow the pathways to coexist and maintain their unique functions, are discussed.