Molecular Mechanisms of Ventricular Hypoplasia

  1. D. SRIVASTAVA,
  2. P.D. GOTTLIEB, and
  3. E.N. OLSON
  1. Departments of *Pediatrics and †Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148; ‡Section of Molecular Genetics and Microbiology, University of Texas, Austin, Texas 78712

This extract was created in the absence of an abstract.

Excerpt

Hypoplasia of either the right or left ventricle is compatible with intrauterine life but has lethal consequencesin the newborn period. Although they are rare, the severity of hypoplastic ventricular conditions results in the single largest contribution to childhood mortality from congenital heart disease. Understanding the molecular andphysiologic cues that initiate ventricular specification,growth, and enlargement is essential for future diagnostic, preventive, and therapeutic approaches...

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