Cytoplasmic and Nuclear Architecture in Cells and Tissue: Form, Functions, and Mode of Assembly
This extract was created in the absence of an abstract.
Excerpt
The form and complexity of multicellular tissue are the salient features that distinguish the metazoa and metaphyta from unicellular organisms. Can we hope to understand the principles governing the development of tissue form and function with our present molecular approaches? It must give us pause that test-tube biochemistry often fails to detect differences between such evolutionarily distant organisms as coelenterates and vertebrates. Men and jellyfish differ principally in the architecture and interactions of their tissues and constituent cells; it is these structures that are formed and reworked in evolution, reflecting the adaptive changes in DNA (King and Wilson 1975). Understanding how form and pattern arise from genomic information would seem to be the ultimate goal of cell biology; possible approaches are beginning to emerge.
The complex networks and laminae of the cytoplasm and nucleus incorporate at least one third of the cellular proteins (Lenk et al. 1977; Cervera et al....
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↵* Present address: University of Iowa, College of Medicine, Department of Biochemistry, Iowa City, Iowa
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↵† Present address: Weizmann Institute of Science, Department of Genetics, Rehovot, Israel
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↵‡ Present address: Children's Hospital Medical Center, Harvard Medical School, Department of Pediatric Research, Boston, Massachusetts.
