Induction of Immunoglobulin Synthesis in Abelson Murine Leukemia Virus-transformed Mouse Lymphoma Cells in Culture
This extract was created in the absence of an abstract.
Excerpt
Several G-type RNA tumor viruses cause lymphocytic leukemia in the mouse, arising in cells of the thymus (Gross 1951; Moloney 1960). In 1969, a new type of RNA tumor virus was isolated from a Moloney leukemia virus-infected mouse that had been treated from birth with the hormone prednisolone (Abelson and Rabstein 1969, 1970). This virus, called Abelson murine leukemia virus (A-MuLV), induces nonthymic lymphomas with a short latent period. The first proliferative changes after virus infection were found to take place in bone marrow cells (Siegler et al. 1972). It therefore appears likely that precursor cells of lymphocytes, abundant in bone marrow, could be the target of transformation. These transformed cells may, in fact, belong to the bursa-equivalent (B) lymphocyte lineage since injection of A-MuLV into pristane (2,6,10,14-tetramethylpentadecane)-conditioned adult BALB/c mice caused development of plasmacytomas and lymphosarcomas (Potter et al. 1973). Furthermore, the tumor cells do not express the theta...
