Infectious DNA from Cells Infected with Rous Sarcoma Virus, Reticuloendotheliosis Virus or Rous-associated Virus-0
This extract was created in the absence of an abstract.
Excerpt
The demonstration of infectious DNA in cells transformed by Rous sarcoma virus (RSV) is the most direct evidence for the existence of a DNA provirus intermediate in the replication of the RNA tumor viruses. The original observation of infectious RSV DNA by Hill and Hillova (1971, 1972) has been confirmed and extended by the work of Svoboda et al. (1972, 1973), Montagnier and Vigier (1972) and Lacour et al. (1972). In this report we describe a more efficient and quantitative assay for infectious RSV DNA and extend the observation of infectious DNA to the reticuloendotheliosis viruses (REV), a recently described group of avian RNA tumor viruses whose virions contain a DNA polymerase (Peterson et al. 1972; Mizutani and Temin 1973; Kangand Temin 1973). We also describe two further applications of the quantitative assay of infectious viral DNA. The first is the determination of the size of avian sarcoma virus and...
