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Volume 1, Issue 2

Redefining the differences in gene content between and using large-scale comparative genomics Open Access

Abstract

, the causative agent of plague, is best known for historical pandemics, but still actively causes disease in many parts of the world. is a recently derived clone of the pathogenic species , but is more associated with human infection. Numerous studies have documented genomic changes since the two species differentiated, although all of these studies used a relatively small sample set for defining these differences. In this study, we compared the complete genomic content between a diverse set of and genomes, and identified unique loci that could serve as diagnostic markers or for better understanding the evolution and pathogenesis of each group. Comparative genomics analyses also identified subtle variations in gene content between individual monophyletic clades within these species, based on a core genome single nucleotide polymorphism phylogeny that would have been undetected in a less comprehensive genome dataset. We also screened loci that were identified in other published studies as unique to either species and generally found a non-uniform distribution, suggesting that the assignment of these unique genes to either species should be re-evaluated in the context of current sequencing efforts. Overall, this study provides a high-resolution view into the genomic differences between and , demonstrating fine-scale differentiation and unique gene composition in both species.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): comparative genomics , evolution , genomics and Yersinia pestis
© 2015 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
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2015-08-03
2024-04-19
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Redefining the differences in gene content between Yersinia pestis and Yersinia pseudotuberculosis using large-scale comparative genomics
M Gen 1, e000028 (2015); https://doi.org/10.1099/mgen.0.000028
/content/journal/mgen/10.1099/mgen.0.000028
/content/journal/mgen/10.1099/mgen.0.000028
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