Cochlear Implantation and Perioperative Management in Autoimmune Inner Ear Disease

Supplemental Digital Content is available in the text.


Data items
10a List and define all outcomes for which data were sought.Specify whether all results that were compatible with each outcome domain in each study were sought (e.g. for all measures, time points, analyses), and if not, the methods used to decide which results to collect.
4, Table 2 10b List and define all other variables for which data were sought (e.g.participant and intervention characteristics, funding sources).Describe any assumptions made about any missing or unclear information.

4, Table 2
Study risk of bias assessment 11 Specify the methods used to assess risk of bias in the included studies, including details of the tool(s) used, how many reviewers assessed each study and whether they worked independently, and if applicable, details of automation tools used in the process.

4, Supplemental Digital Content 4
Effect measures 12 Specify for each outcome the effect measure(s) (e.g.risk ratio, mean difference) used in the synthesis or presentation of results.

5-6
Synthesis methods 13a Describe the processes used to decide which studies were eligible for each synthesis (e.g.tabulating the study intervention characteristics and comparing against the planned groups for each synthesis (item #5)).

5-6
13b Describe any methods required to prepare the data for presentation or synthesis, such as handling of missing summary statistics, or data conversions.

5-6
13c Describe any methods used to tabulate or visually display results of individual studies and syntheses.5-6 13d Describe any methods used to synthesize results and provide a rationale for the choice(s).If meta-analysis was performed, describe the model(s), method(s) to identify the presence and extent of statistical heterogeneity, and software package(s) used.

5-6
13e Describe any methods used to explore possible causes of heterogeneity among study results (e.g.subgroup analysis, meta-regression).

5-6
13f Describe any sensitivity analyses conducted to assess robustness of the synthesized results.

5-6
Reporting bias 14 Describe any methods used to assess risk of bias due to missing results in a synthesis (arising from reporting biases).4, Certainty assessment

PRISMA 2020 Checklist
15 Describe any methods used to assess certainty (or confidence) in the body of evidence for an outcome.5-6

Study selection 16a
Describe the results of the search and selection process, from the number of records identified in the search to the number of studies included in the review, ideally using a flow diagram.
Figure 1 16b Cite studies that might appear to meet the inclusion criteria, but which were excluded, and explain why they were excluded.N/A

Study characteristics
17 Cite each included study and present its characteristics.Table 1 Risk of bias in studies 18 Present assessments of risk of bias for each included study.Supplemental Digital Content 4

Results of individual studies
19 For all outcomes, present, for each study: (a) summary statistics for each group (where appropriate) and (b) an effect estimate and its precision (e.g.confidence/credible interval), ideally using structured tables or plots.

Table 2 Results
of syntheses 20a For each synthesis, briefly summarise the characteristics and risk of bias among contributing studies.Supplemental Digital Content 420b Present results of all statistical syntheses conducted.If meta-analysis was done, present for each the summary estimate and its precision (e.g.confidence/credible interval) and measures of statistical heterogeneity.If comparing groups, describe the direction of the effect.8-920cPresentresults of all investigations of possible causes of heterogeneity among study results.8-920dPresentresults of all sensitivity analyses conducted to assess the robustness of the synthesized results.24aProvideregistration information for the review, including register name and registration number, or state that the review was not registered.324bIndicate where the review protocol can be accessed, or state that a protocol was not prepared.3 24c Describe and explain any amendments to information provided at registration or in the protocol.N/A Support 25 Describe sources of financial or non-financial support for the review, and the role of the funders or sponsors in the review.N/A PRISMA

2020 Checklist Section and Topic Item # Checklist item Page # or Location where item is reported
Report which of the following are publicly available and where they can be found: template data collection forms; data extracted from included studies; data used for all analyses; analytic code; any other materials used in the review.Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al.The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.BMJ 2021;372:n71.doi: 10.1136/bmj.

TABLE .
Audiometric and speech perception outcomes before and after CI in patients with AIED.Northwestern University Auditory Test Number 6; HINT, hearing in noise test; CID, central institute for the deaf sentence test; dB, decibels; HL, hearing loss; -, no data available; VKH, Vogt-Koyanagi-Harada disease; CS, Cogan syndrome; BKB, Bamford-Kowal-Bench sentence test; FFSA, free field speech audiometry; CUNY, City University of New York sentence test; CNC, consonant-nucleus-consonant word list; CS, cogan syndrome; SNHL, sensorineural hearing loss; PB, phonetically balanced word list; K-CID, Korean version-central institute for the deaf sentence test; FMT, Freiburg Monosyllabic word Test; HSM, Hochmair-Schulz-Moser sentence test; AB, Arthur Boothroyd word list; AID, autoimmune disease; SNHL, sensorineural hearing loss; RP, relapsing polychondritis; PBK-50, phonetically balanced kindergarten-50 word list.HINT for all patients, except for 3 patients for whom CID was used; individual test scores were not reported b CID, CUNY, and HINT results were collectively reported in this study; individual test scores were not reported c Values are reported as mean, or mean ± SD when SD data available in original paper a