Clinical InvestigationQuantification of Aortic Stiffness to Predict the Degree of Left Ventricular Diastolic Function
Section snippets
Subjects and Protocol
A total of 800 consecutive patients who were diagnosed as having essential hypertension were entered into this study. Patients were referred or self-referred to the outpatient hypertensive unit of our institution. Patients with a history of atherosclerotic cardiovascular disease, congenital heart disease, severe valvular disease, cardiomyopathy, atrial fibrillation, impulse conduction disturbances, chronic renal failure or any other concurrent systemic illness were excluded from the study.
RESULTS
Patients were divided into 3 groups based on the criteria described earlier; the 3 groups did not differ significantly with respect to sex, body mass index (BMI), smoking status, dyslipidemia and renal function (Table 1). Compared with group B and group C, group A (normal diastolic function group) was characterized by lower age (P < 0.001), lower rate of diabetes mellitus (P < 0.001) and lower systolic and diastolic BP and pulse pressure (P < 0.001). Moreover, group A had a lower
DISCUSSION
The findings of this study showed that in a cohort of subjects with newly diagnosed uncomplicated essential hypertension, increased aortic stiffness was significantly associated with the presence of LV diastolic dysfunction, as detected by pulsed TDI of the mitral annulus. We also found that PWV was significantly related to the degree of cardiac diastolic dysfunction. In some studies, 30% to 50% of patients hospitalized for congestive HF were diagnosed as having diastolic dysfunction, and thus
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This study was supported by Chang Gung Memorial Hospital, Contract No. CMRPG, Chiayi/Taiwan.