SPECIAL ARTICLE
Childhood-Onset Schizophrenia: Timely Neurobiological Research

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ABSTRACT

Objective

To review timely research on childhood-onset schizophrenia in view of advances in biological research on, and neurodevelopmental theories of, the later-onset disorder.

Method

Research issues are outlined including further clarification of ICD- and DSM-defined childhood schizophrenia, and differentiation from autism “spectrum” and other subtle, chronic developmental disorders. Key neurobiological advances are reviewed for which child studies are relevant and feasible. Conclusion: It is anticipated that narrowly defined childhood-onset schizophrenics will constitute a predominately male population. A high rate of family illness or chromosomal and/or brain developmental abnormalities, which will be instructive regarding the pathophysiology of later-onset schizophrenia, is expected.

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