Activation of Vagal Afferents in the Rat Duodenum by Protein Digests Requires PepT11,2
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Key Words
nutrient detection
protein
vagal afferents
PepT1
cholecystokinin
Abbreviations
4-AMBA
4-aminomethylbenzoic acid
4-APAA
aminophenylacetic acid
CCK
cholecystokinin
CCK1R
cholecystokinin 1 receptor
ERK
extracellular signal-regulated kinase
GLP
glucagon-like peptide
i.a.
intra-arterial
i.d.
intraduodenal
IGP
intragastric pressure
MAP
mitogen-activated protein kinase
RQ
response quotient
Cited by (0)
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Presented in part at Experimental Biology 04, April 17–21, 2004, Washington, DC [Liou, A., Darcel, N., Tomé, D. & Raybould, H. E. (2004) Vagally-mediated inhibition of gastric motility in response to protein digest is dependent on the oligopeptide transporter PepT1. FASEB J. 18: A230 (abs.)] and [Darcel, N., Liou, A., Tomé, D. & Raybould, H. E. (2004) Proton-coupled oligopeptide transporter PepT1 is required for duodenal vagal afferent activation by protein digest. FASEB J. 18: A456 (abs.)].
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Supported by National Institutes of Health RO1DK 41004 (H.E.R.) and by Achievement Rewards for College Scientists Foundation scholarship (A.L.).
Copyright © 2005 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.