Elsevier

Annals of Oncology

Volume 26, Issue 10, October 2015, Pages 2168-2173
Annals of Oncology

original articles
sarcoma
Sorafenib in patients with locally advanced and metastatic chordomas: a phase II trial of the French Sarcoma Group (GSF/GETO)

https://doi.org/10.1093/annonc/mdv300Get rights and content
Under a Creative Commons license
open access

Abstract

Background

There is no consensual treatment of locally advanced or metastatic chordomas.

Patients and methods

We conducted a multicenter, open-label, uncontrolled phase II trial of sorafenib (800 mg/day). The primary end point was the 9-month progression-free rate according to RECIST 1.1. All patients had documented progressive disease at the time of study entry.

Results

Twenty-seven patients were enrolled between May 2011 and January 2014. The median age was 64 (range, 30–86) years. There were 17 men and 10 women. Twelve patients had been previously treated with chemotherapy and molecularly targeted agents. The maximum toxicity grade per patient was grade 3 in 21 cases (77.8%) and grade 4 in 4 cases (14.8%). Sorafenib provided an intent-to-treat best objective response of 1/27 [3.7%; 95% confidence interval (CI) 0.1% to 19.0%], a 9-month progression-free rate of 73.0% (95% CI 46.1–88.0) and a 12-month overall survival rate of 86.5% (95% CI 55.8–96.5). Survival curves were similar in pretreated and not pretreated patients.

Discussion

Additional clinical trials further exploring sorafenib as a treatment of locally advanced or metastatic chordomas are warranted.

Key words

sorafenib
phase II trial
chordoma

Cited by (0)

Presented in part at the 2015 Annual Meeting Abstract, Chicago, IL, USA, 29 May–2 June 2015.