Study on the preparation technology of Sanqi Shangyao smeared films for percutaneous absorption

Objective: The dosage form of Sanqi Shangyao tablets was reformed and made smeared films. Methods: PVA-124 was used as film forming material, glycerol as plasticizer, Twain 80 as surfactant and azone as penetration enhancer. On the basis of the single factor test, the orthogonal test L₉ (3⁴) was used to screen the matrix prescription, and the optimum matrix ratio was obtained by investigating the fluidity, color, flexibility, film forming time and the appearance uniformity of the coating agent. Results: The best substrate ratio was Twain 80 0.5 g, PVA-124 4.0 g, glycerol 2.0 g, azone 0.3 g. Conclusion: The proportion of the smeared films prepared by orthogonal test is stable. The film forming time is short, and the preparation process is simple and feasible.