Abstract
Objective: To study the mechanism of anti-inflammation of Polygonum perfoliatum L by network pharmacology. Method: The active ingredients of Polygonum perfoliatum L were screened using TCMSP database, the active ingredients-target network and protein interaction network were established. The biological functions and pathways involved in the target were analyzed. Results: 11 active ingredients were obtained by screening. The network analysis indicated that the active components of Polygonum perfoliatum L involved 183 protein targets including Serpinel, Akt1, Nos3, Tnf, Casp8, Bcl2l1and multiple protein targets related to the MAPK signaling pathway, etc. The medicine had anti-inflammatory effects by regulating many signaling pathways such as PI3K-Akt signaling pathway, MAPK signaling pathway, Toll-like receptor signaling pathway, and HIF-1 signaling pathway. Conclusion: This study reflects the medicine multi-component-multi-target-multi-path therapy. It provides new ideas and new directions for further research on the mechanism of anti-inflammatory effects of Polygonum perfoliatum L.
Export citation and abstract BibTeX RIS
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.