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Small-angle X-ray scattering probe of intermolecular interaction in red blood cells*

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©2015 Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Sciences and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd
, , Citation Guan-Fen Liu et al 2015 Chinese Phys. C 39 038001 DOI 10.1088/1674-1137/39/3/038001

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dongyh@ihep.ac.cn

Author affiliations

1 Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China

Dates

  1. Received 7 April 2014
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1674-1137/39/3/038001

Abstract

With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells.

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Footnotes

  • * 

    Supported by National Basic Research Program of China (2009CB918600) and National Natural Science Foundation of China (10979005)

10.1088/1674-1137/39/3/038001