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The Challenges of Carbapenemase-Producing Enterobacteriaceae and Infection Prevention: Protecting Patients in the Chaos

Published online by Cambridge University Press:  02 January 2015

Patrice Savard ,
Karen C. Carroll ,
Lucy E. Wilson  and
Trish M. Perl
Patrice Savard*
Affiliation:
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; and Epidemiology and Infection Prevention, Johns Hopkins Health System, Baltimore, Maryland
Karen C. Carroll
Affiliation:
Division of Medical Microbiology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Lucy E. Wilson
Affiliation:
Prevention and Health Promotion Administration, Infectious Disease Bureau, Maryland Department of Health and Mental Hygiene, Baltimore, Maryland
Trish M. Perl
Affiliation:
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; and Epidemiology and Infection Prevention, Johns Hopkins Health System, Baltimore, Maryland
*
Epidemiology and Infection Prevention, The Johns Hopkins Health System, 327 A Billings Building, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21287 (patrice.savard.chum@ssss.gouv.qc.ca)
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Abstract

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Type
Commentary
Information
Infection Control & Hospital Epidemiology , Volume 34 , Issue 7 , July 2013 , pp. 730 - 739
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2013

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References

1.Bush, K, Jacoby, GA. Updated functional classification of β-lactamases. Antimicrob Agents Chemother Mar 2010;54(3):969–976.CrossRefGoogle ScholarPubMed
2.Knothe, H, Shah, P, Krcmery, V, Antal, M, Mitsuhashi, S. Transferable resistance to cefotaxime, cefoxitin, cefamandole and ce-furoxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection 1983;11(6):315–317.CrossRefGoogle ScholarPubMed
3.Paterson, DL, Bonomo, RA. Extended-spectrum β-lactamases: a clinical update. Clin Microbiol Rev 2005;18(4):657–686.CrossRefGoogle ScholarPubMed
4.Philippon, A, Labia, R, Jacoby, G. Extended-spectrum β-lactamases. Antimicrob Agents Chemother 1989;33(8):1131–1136.CrossRefGoogle ScholarPubMed
5.Bartlett, JG. A call to arms: the imperative for antimicrobial stewardship. Clin Infect Dis 2011;53(suppl 1):S4–S7.CrossRefGoogle Scholar
6.Queenan, AM, Bush, K. Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev 2007;20(3):440–458.CrossRefGoogle ScholarPubMed
7.Yigit, H, Queenan, AM, Anderson, GJ, et al. Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001;45(4):1151–1161.CrossRefGoogle ScholarPubMed
8.Arnold, RS, Thom, KA, Sharma, S, Phillips, M, Johnson, JK, Morgan, DJ. Emergence of Klebsiella pneumoniae carbapenemase-producing bacteria. South Med J 2011;104(1):40–45.CrossRefGoogle ScholarPubMed
9.Cornaglia, G, Giamarellou, H, Rossolini, GM. Metallo-β-lacta-mases: a last frontier for β-lactams? Lancet Infect Dis 2011;11(5): 381–393.CrossRefGoogle ScholarPubMed
10.Kumarasamy, KK, Toleman, MA, Walsh, TR, et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010;10(9):597–602.CrossRefGoogle Scholar
11.Centers for Disease Control and Prevention. Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. Morb Mortal Wkly Rep 2009;58(10):256–260.Google Scholar
12.World Health Organization. The evolving threat of antimicrobial resistance: options for action, http://www.who.int/patientsafety/implementation/amr/publication/en/.Google Scholar
13.Savard, P, Perl, TM. A call for action: managing the emergence of multidrug-resistant Enterobacteriaceae in the acute care settings. Curr Opin Infect Dis 2012;25(4):371–377.CrossRefGoogle Scholar
14.Kallen, AJ, Srinivasan, A. Current epidemiology of multidrug-resistant gram-negative bacilli in the United States. Infect Control Hosp Epidemiol 2010;31(suppl 1):S51–S54.CrossRefGoogle ScholarPubMed
15.Gupta, N, Limbago, BM, Patel, JB, Kallen, AJ. Carbapenem-resistant Enterobacteriaceae. epidemiology and prevention. Clin Infect Dis 2011;53(1):60–67.CrossRefGoogle ScholarPubMed
16.Cagnacci, S, Gualco, L, Roveta, S, et al. Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-β-lactamase: first Italian outbreak. J Antimicrob Chemother 2008;61(2):296–300.CrossRefGoogle ScholarPubMed
17.Tato, M, Coque, TM, Ruiz-Garbajosa, P, et al. Complex clonal and plasmid epidemiology in the first outbreak of Enterobacteriaceae infection involving VIM-1 metallo-β-lactamase in Spain: toward endemicity? Clin Infect Dis 2007;45(9):1171–1178.CrossRefGoogle ScholarPubMed
18.Vatopoulos, A. High rates of metallo-beta-lactamase-producing Klebsiella pneumoniae in Greece: a review of the current evidence. Euro Surveill 2008;13(4):pii = 8023.CrossRefGoogle ScholarPubMed
19.Canton, R, Akova, M, Carmeli, Y, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 2012;18(5):413–431.CrossRefGoogle ScholarPubMed
20.Prior, AR, Roche, C, Lynch, M, Kelly, S, O'Rourke, K, Crowley, B. First identified case of VIM-producing carbapenem-resistant Klebsiella pneumoniae in the Republic of Ireland associated with fatal outcome. Euro Surveill 2010;15(50):pii= 19752.CrossRefGoogle ScholarPubMed
21.Samuelsen, Ø, Toleman, MA, Hasseltvedt, V, et al. Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance. Clin Microbiol Infect 2011;17(11):1811–1816.CrossRefGoogle ScholarPubMed
22.Kristóf, K, Tóth, Á, Damjanova, I, et al. Identification of bla VIM-4 gene in the internationally successful Klebsiella pneumoniae STI 1 clone and in a Klebsiella oxytoca strain in Hungary. J Antimicrob Chemother 2010;65(6):1303–1305.CrossRefGoogle Scholar
23.Montealegre, MC, Correa, A, Briceño, DF, et al. Novel VIM met-allo-β-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia. Antimicrob Agents Chemother 2011;55(5):2428–2430.CrossRefGoogle ScholarPubMed
24.Centers for Disease Control and Prevention. Update: detection of a Verona integron-encoded metallo-beta-lactamase in Klebsiella pneumoniae-United States, 2010. Morb Mortal Wkly Rep 2010;59(37):1212.Google Scholar
25.Limbago, BM, Rasheed, JK, Anderson, KF, et al. IMP-producing carbapenem-resistant Klebsiella pneumoniae in the United States. J Clin Microbiol 2011;49(12):4239–4245.CrossRefGoogle ScholarPubMed
26.Struelens, MJ, Monnet, DL, Magiorakos, AP, Santos O'Connor, F, Giesecke, J. New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe. Euro Surveill 2010;15(46):pii= 19716.CrossRefGoogle ScholarPubMed
27.Perry, JD, Naqvi, SH, Mirza, IA, et al. Prevalence of faecal carriage of Enterobacteriaceae with NDM-1 carbapenemase at military hospitals in Pakistan, and evaluation of two chromogenic media. J Antimicrob Chemother 2011;66(10):2288–2294.CrossRefGoogle ScholarPubMed
28.Rolain, JM, Parola, P, Cornaglia, G. New Delhi metallo-beta-lactamase (NDM-1): towards a new pandemia? Clin Microbiol Infect 2010;16(12):1699–1701.CrossRefGoogle ScholarPubMed
29.Nordmann, P, Poirel, L, Walsh, TR, Livermore, DM. The emerging NDM carbapenemases. Trends Microbiol 2011;19(12):588–595.CrossRefGoogle ScholarPubMed
30.Walsh, TR. Emerging carbapenemases: a global perspective. Int J Antimicrob Agents 2010;36(suppl 3):S8–S14.CrossRefGoogle ScholarPubMed
31.Poirel, L, Lagrutta, E, Taylor, P, Pham, J, Nordmann, P. Emergence of metallo-/β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. Antimicrob Agents Chemother 2010;54(11):4914–4916.CrossRefGoogle ScholarPubMed
32.Tijet, N, Alexander, DC, Richardson, D, et al. New Delhi metallo-β-lactamase, Ontario, Canada. Emerg infect Dis 2011;17(2):306–307.CrossRefGoogle ScholarPubMed
33.Centers for Disease Control and Prevention. Carbapenem-resistant Enterobacteriaceae containing New Delhi metallo-beta-lactamase in two patients-Rhode Island, March 2012. Morb Mortal Wkly Rep 2012;61(24):446–448.Google Scholar
34.Savard, P, Gopinath, R, Zhu, W, et al. First NDM-positive Salmonella sp. strain identified in the United States. Antimicrob Agents Chemother 2011;55(12):5957–5958.CrossRefGoogle ScholarPubMed
35.Centers for Disease Control and Prevention. Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase- United States, 2010 Morb Mortal Wkly Rep 2010;59(24):750.Google Scholar
36.Mochon, AB, Garner, OB, Hindier, JA, et al. New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies. J Clin Microbiol 2011;49(4): 1667–1670.CrossRefGoogle ScholarPubMed
37.Poirel, L, Lagrutta, E, Taylor, P, Pham, J, Nordmann, P. Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. Antimicrob Agents Chemother 2010;54(11):4914–4916.CrossRefGoogle ScholarPubMed
38.Gregory, CJ, Llata, E, Stine, N, et al. Outbreak of carbapenem-resistant Klebsiella pneumoniae in Puerto Rico associated with a novel carbapenemase variant. Infect Control Hosp Epidemiol 2010;31(5):476–484.CrossRefGoogle ScholarPubMed
39.Poirel, L, Hervé, V, Hombrouck-Alet, C, Nordmann, P. Long-term carriage of NDM-1-producing Escherichia coli. J Antimicrob Chemother 2011;66(9):2185–2186.CrossRefGoogle ScholarPubMed
40.Nordmann, P, Cuzon, G, Naas, T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009;9(4):228–236.CrossRefGoogle ScholarPubMed
41.Patel, G, Huprikar, S, Factor, SH, Jenkins, SG, Calfee, DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008;29(12):1099–1106.CrossRefGoogle ScholarPubMed
42.Souli, M, Galani, I, Antoniadou, A, et al. An outbreak of infection due to β-lactamase Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in a Greek university hospital: molecular characterization, epidemiology, and outcomes. Clin Infect Dis 2010;50(3):364–373.CrossRefGoogle Scholar
43.Livermore, D, Department of Health Advisory Committee on Antimicrobial Resistance and Healthcare Associated Infection. Advice on carbapenemase producers: recognition, infection control and treatment. Health Protection Agency website, http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1294740725984. Published 2011.Google Scholar
44.Public Health Agency of Canada. Guidance: infection prevention and control measures for healthcare workers in all healthcare settings. Carbapenem-resistant gram-negative bacilli, http://www.phac-aspc.gc.ca/nois-sinp/guide/ipcm-mpci/pdf/guide-eng.pdf. Published 2010.Google Scholar
45.CINQ (Comité sur les infections nosocomiales du Québec). Avis et recommandations: prévention et contrôle de la transmission des entérobactéries productrices de carbapénémases dans les milieux de soins aigus du Québec. Institut National de Santé Publique du Québec website, http://www.mspq.qc.ca/pdf/publications/1168_PreventionTransmissionEnterobactCarbapenemases.pdf. Published October 2010.Google Scholar
46.Haut Conseil de la santé publique. Maîtrise de la diffusion des bactéries multirésistantes aux antibiotiques importées en France par des patients rapatriés ou ayant des antécédents d'hospitalisation à l'étranger. 2nd version, http://www.hcsp.fr/docspdf/avisrapports/hcspr20101116_bmrimport.pdf. Published November 2010.Google Scholar
47.Carmeli, Y, Akova, M, Cornaglia, G, et al. Controlling the spread of carbapenemase-producing gram-negatives: therapeutic approach and infection control. Clin Microbiol Infect 2010;16(2): 102–111.CrossRefGoogle ScholarPubMed
48.Grundmann, H, Livermore, DM, Giske, CG, et al. Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill 2010;15(46): pii= 19711.CrossRefGoogle ScholarPubMed
49.Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion. Guidance for control of carbapenem-resistant Enterobacteriaceae (CRE). 2012 CRE toolkit. http://www.cdc.gov/hai/organisms/cre/cre-toolkit/index.html. Updated March 5, 2013.Google Scholar
50.Kollef, MH, Golan, Y, Micek, ST, Shorr, AF, Restrepo, MI. Appraising contemporary strategies to combat multidrug resistant gram-negative bacterial infections: proceedings and data from the Gram-Negative Resistance Summit. Clin Infect Dis 2011;53(suppl 2):S33–S58.CrossRefGoogle ScholarPubMed
51.Wendt, C, Schütt, S, Dalpke, AH, et al. First outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in Germany. Eur J Clin Microbiol Infect Dis 2010;29(5):563–570.CrossRefGoogle ScholarPubMed
52.Doern, CD, Dunne, WM Jr, Burnham, CA. Detection of Klebsiella pneumoniae carbapenemase (KPC) production in non-Klebsiella pneumoniae Enterobacteriaceae isolates by use of the Phoenix, Vitek 2, and disk diffusion methods. J Clin Microbiol 2011;49(3): 1143–1147.CrossRefGoogle ScholarPubMed
53.Clinical and Laboratory Standards Institute (CLSI). 2010. Performance standards for antimicrobial susceptibility testing: twentieth informational supplement (June 2010 update). Wayne, PA: CLSI, 2010. CLSI document M100-S20-U.Google Scholar
54.Pasteran, F, Lucero, C, Soloaga, R, Rapoport, M, Corso, A. Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae? J Clin Microbiol 2011;49(2):697–701.CrossRefGoogle ScholarPubMed
55.Seah, C, Low, DE, Patel, SN, Melano, RG. Comparative evaluation of a chromogenic agar medium, the modified Hodge test, and a battery of meropenem-inhibitor discs for detection of carbapenemase activity in Enterobacteriaceae. J Clin Microbiol 2011;49(5):1965–1969.CrossRefGoogle Scholar
56.Girlich, D, Poirel, L, Nordmann, P. Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae. J Clin Microbiol 2012;50(2):477–479.CrossRefGoogle ScholarPubMed
57.Nordmann, P, Girlich, D, Poirel, L. Detection of carbapenemase producers in Enterobacteriaceae using a novel screening medium. J Clin Microbiol 2012;50:(8):2761–2766.CrossRefGoogle ScholarPubMed
58.Vrioni, G, Daniii, I, Voulgari, E, et al. Comparative evaluation of a prototype chromogenic medium (chromID CARBA) for detecting carbapenemase-producing Enterobacteriaceae in surveillance rectal swabs. J Clin Microbiol 2012;50(6):1841–1846.CrossRefGoogle ScholarPubMed
59.Wilkinson, KM, Winstanley, TG, Lanyon, C, Cummings, SP, Raza, MW, Perry, JD. Comparison of four chromogenic culture media for carbapenemase-producing Enterobacteriaceae. J Clin Microbiol 2012;50(9):3102–3104.CrossRefGoogle ScholarPubMed
60.Siegel, JD, Rhinehart, E, Jackson, M, et al. Management of multidrug-resistant organisms in healthcare settings, 2006. Healthcare Infection Control Practices Advisory Committee (HICPAC) website, http://www.cdc.gov/hicpac/mdro/mdro_toc.html. Updated December 29, 2009.Google Scholar
61.Won, SY, Munoz-Price, LS, Lolans, K, Hota, B, Weinstein, RA, Hayden, MK. Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Clin Infect Dis 2011;53(6):532–540.CrossRefGoogle ScholarPubMed
62.Marchaim, D, Chopra, T, Bogan, C, et al. The burden of multidrug-resistant organisms on tertiary hospitals posed by patients with recent stays in long-term acute care facilities. Am J Infect Control 2012;40(8):760–765.CrossRefGoogle ScholarPubMed
63.Tamma, PD, Savard, P, Pal, T, Sonnevend, A, Perl, TM, Milstone, AM. An outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2012;33(6):631–634.CrossRefGoogle Scholar
64.Munoz-Price, LS, Hayden, MK, Lolans, K, et al. Successful control of an outbreak of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae at a long-term acute care hospital. Infect Control Hosp Epidemiol 2010;31(4):341–347.CrossRefGoogle Scholar
65.Naas, T, Cuzon, G, Babies, A, et al. Endoscopy-associated transmission of carbapenem-resistant Klebsiella pneumoniae producing KPC-2 β-lactamase. J Antimicrob Chemother 2010;65(6): 1305–1306.CrossRefGoogle ScholarPubMed
66.Carbonne, A, Thiolet, JM, Fournier, S, et al. Control of a multi-hospital outbreak of KPC-producing Klebsiella pneumoniae type 2 in France, September to October 2009. Euro Surveill 2010;15(48):pii= 19734.CrossRefGoogle ScholarPubMed
67.Schechner, V, Kotlovsky, T, Tarabeia, J, et al. Predictors of rectal carriage of carbapenem-resistant Enterobacteriaceae (CRE) among patients with known CRE carriage at their next hospital encounter. Infect Control Hosp Epidemiol 2011;32(5):497–503.CrossRefGoogle ScholarPubMed
68.Passaretti, CL, Otter, JA, Reich, NG, et al. An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms. Clin Infect Dis 2013;56(1):27–35.CrossRefGoogle ScholarPubMed
69.Lee, BY, Bartsch, SM, Wong, KF, et al. Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone. Health Aff 2012;31(10):2295–2303.CrossRefGoogle ScholarPubMed
70.Akova, M, Daikos, GL, Tzouvelekis, L, Carmeli, Y. Interventional strategies and current clinical experience with carbapenemase-producing gram-negative bacteria. Clin Microbiol Infect 2012;18(5):439–448.CrossRefGoogle ScholarPubMed
71.Schechner, V, Kotlovsky, T, Kazma, M, et al. Asymptomatic rectal carriage of bla KPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected? Clin Microbiol Infect 2013;19(5):451–456.CrossRefGoogle ScholarPubMed
72.Rapp, RP, Urban, C. Klebsiella pneumoniae carbapenemases in Enterobacteriaceae: history, evolution, and microbiology concerns. Pharmacotherapy 2012;32(5):399–407.CrossRefGoogle ScholarPubMed
73.Livermore, DM. Current epidemiology and growing resistance of gram-negative pathogens. Korean J Intern Med 2012;27(2): 128–142.CrossRefGoogle ScholarPubMed