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HTLV-I-associated myelopathy: Are ferritin, S100β protein, or guanine nucleotides CSF markers of disease?

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Abstract

In southern Brazil, there is an endemic high prevalence foci of HTLV-I and HTLV-II infection. HTLV-infected individuals may develop HAM/TSP. Little is known about HAM/TSP pathogenesis and there is a lack of disease progression markers. This study investigated ferritin, S-100β protein, and guanine nucleotides (GN) concentrations in the CSF of 18 patients with HAM/TSP. In HAM/TSP patients, concentrations of ferritin and S100β were increased, whereas GMP was reduced. CSF ferritin, S100β, and GN are potential markers for HAM/TSP.

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Authors and Affiliations

  1. Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

    Andrea Regner

  2. School of Medicine, Lutheran University of Brazil, Canoas, Brazil

    Andrea Regner

  3. Comprehensive Cancer Center, Lutheran University of Brazil, Canoas, Brazil

    Andrea Regner

  4. Virion-HTLV Working and Study Group, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil

    Ottomar Bianchini, Claudio Jardim & Marcio Menna-Barreto

  5. Division of Neurology, Pontificial Catholic University (PUCRS), Av. Engenheiro Alfredo Correa Daudt 455, CEP 90480-120, Porto Alegre, RS, Brazil

    Marcio Menna-Barreto

Authors
  1. Andrea Regner
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  2. Ottomar Bianchini
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  3. Claudio Jardim
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  4. Marcio Menna-Barreto
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Correspondence to Marcio Menna-Barreto.

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Regner, A., Bianchini, O., Jardim, C. et al. HTLV-I-associated myelopathy: Are ferritin, S100β protein, or guanine nucleotides CSF markers of disease?. Journal of NeuroVirology 8, 64–67 (2002). https://doi.org/10.1080/135502802317247839

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  • DOI: https://doi.org/10.1080/135502802317247839

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