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Weight and body composition in a cohort of HIV-positive men and women

Published online by Cambridge University Press:  02 January 2007

JE Forrester ,
D Spiegelman ,
M Woods ,
TA Knox ,
JM Fauntleroy  and
SL Gorbach
JE Forrester*
Affiliation:
Department of Family Medicine and Community Health, Tufts University School of Medicine, 136 Harrison Avenue (Stearns 203A), Boston, MA 02111, USA
D Spiegelman
Affiliation:
Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA 02 115, USA
M Woods
Affiliation:
Department of Family Medicine and Community Health, Tufts University School of Medicine, 136 Harrison Avenue (Stearns 203A), Boston, MA 02111, USA
TA Knox
Affiliation:
Department of Medicine, New England Medical Center, Boston, MA 02 111, USA
JM Fauntleroy
Affiliation:
Department of Family Medicine and Community Health, Tufts University School of Medicine, 136 Harrison Avenue (Stearns 203A), Boston, MA 02111, USA
SL Gorbach
Affiliation:
Department of Family Medicine and Community Health, Tufts University School of Medicine, 136 Harrison Avenue (Stearns 203A), Boston, MA 02111, USA Department of Medicine, New England Medical Center, Boston, MA 02 111, USA
*
*Corresponding author: Email janet.forrester@tufts.edu
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Abstract

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Objective:

At issue is whether weight loss in HIV infection is a cachectic process, characterised by loss of lean body mass with conservation of fat, or a process of starvation. We present data on body composition from 516 persons at different stages of HIV infection as determined by CD4 counts.

Design:

Cross-sectional analyses of body composition in relation to CD4 count.

Setting:

The baseline data from a prospective cohort study of outcomes in HIV/AIDS in relation to nutritional status in Boston, Massachusetts, USA.

Subjects:

The first 516 subjects with HIV/AIDS to enrol in the study.

Results:

Differences in weight in relation to CD4 counts were present only at CD4 counts of 600 or less (slope below CD4=600: 1.9 kg per 100 CD4 cells, P<0.0001). On average, 68% of the difference in weight over CD4 counts was fat (slope: 1.3 kg fat per 100 CD4 cells, P<0.0001).

Conclusions:

This cross-sectional analysis suggests that weight loss consists principally of fat loss in those persons with adequate fat stores. This observation will need to be confirmed in longitudinal analyses.

Keywords

Body compositionHIVNutritional status
Type
Research Article
Information
Public Health Nutrition , Volume 4 , Issue 3 , June 2001 , pp. 743 - 747
Copyright
Copyright © CABI Publishing 2001

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