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A model of magnesium metabolism in young sheep: transactions between plasma, cerebrospinal fluid and bone

Published online by Cambridge University Press:  09 March 2007

A. B. Robson ,
A. R. Sykes ,
A. E. McKinnon  and
S. T. Bell
A. B. Robson
Affiliation:
Applied Computing, Mathematics and Statistics Group, Applied Management and Computing Division
A. R. Sykes
Affiliation:
Animal and Veterinary Sciences Group, Animal and Food Sciences Division, Lincoln University, Canterbury, New Zealand
A. E. McKinnon*
Affiliation:
Applied Computing, Mathematics and Statistics Group, Applied Management and Computing Division
S. T. Bell
Affiliation:
Animal and Veterinary Sciences Group, Animal and Food Sciences Division, Lincoln University, Canterbury, New Zealand
*
*Corresponding author:, Dr Alan E. McKinnon, fax +64 3 3253839, email mckinnon@lincoln.ac.nz
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Abstract

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An extension of the previously proposed model of Mg metabolism (Robson et al. 1997) has been developed to consider the transactions of Mg that are associated with cerebrospinal fluid (CSF) and bone. The representation of the CSF as a single Mg compartment with uptake from the plasma described by Michaelis–Menten kinetics gives very good agreement with published experiments. Analysis of the available information on resorption of Mg from adult bone indicates that this process makes a negligible contribution to Mg homeostasis and can be omitted from the model.

Keywords

MagnesiumMathematical modellingHypomagnesaemiaGrass tetanySimulation
Type
Research Article
Information
British Journal of Nutrition , Volume 91 , Issue 1 , January 2004 , pp. 73 - 79
Copyright
Copyright © The Nutrition Society 2004

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