Therapeutic Efficacy of Stephania tetrandra S. Moore for treatment of neovascularization of retinal capillary (retinopathy) in diabetes – in vitro study
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Cited by (30)
A review of traditional Chinese medicine on treatment of diabetic retinopathy and involved mechanisms
2020, Biomedicine and PharmacotherapyCitation Excerpt :In addition to inflammatory cascade, the retinal ischaemia and hypoxia can initiate angiogenesis in DR [126,127]. Liang et al. confirmed that the root extract of Stephania tetrandra S. Moore could suppress capillary regeneration of posterior ocular region in DR rats through the activation of tetrandrine [128]. Moreover, accumulating pieces of evidence suggested that hypoxia-activated HIF-1α-VEGF signaling pathway could damage the structure of BRB via promoting retinal angiogenesis in DR [10,129,130].
Fangchinoline supplementation attenuates inflammatory markers in experimental rheumatoid arthritis-induced rats
2019, Biomedicine and PharmacotherapyCitation Excerpt :Tsutsumi et al. [10] reported the anti-hyperglycemic activity of fangchinoline in a mouse model of diabetes. Researchers have also reported the therapeutic efficacy of fangchinoline isolated from Stephania tetrandra S. Moore for the treatment of retinopathy [11]. Shen et al. [33] reported the anti-inflammatory activity of partially purified radix Stephaniae tetrandrae extracts.
In Vitro Propagation and Approaches for Metabolites Production in Medicinal Plants
2012, Advances in Botanical ResearchCitation Excerpt :The use of Fan fang ji roots has been limited to China. Many of its pharmacological properties are relatively well described including its hypotensive activity (Kawashima et al., 1990), its use as a vasodilator (Kim et al., 1997) and an anti-fibrotic (Nan et al., 2000), and its use in coronary disease (Yu et al., 2001) and retinopathy (Liang et al., 2002). Plant secondary metabolites have enormous potential for research and new drug development.
Research advances on the pharmacological effects of tetrandrine
2011, Chinese Journal of Natural MedicinesThe genus Stephania (Menispermaceae): Chemical and pharmacological perspectives
2010, Journal of EthnopharmacologyCitation Excerpt :The effect of fangchinoline was 3.9 fold greater than that of water extract (Tsutsumi et al., 2003). S. tetrandra has a direct effect on the retinal capillary of posterior ocular region and suppressed neovascularization of retinal capillary in streptozotocin diabetic rats through the activation of tetrandrine (Liang et al., 2002). The oral administration of ethanol and aqueous extract (400 mg/kg body weight) of powdered corm of S. hernandifolia significantly (p < 0.05) decreased the blood glucose of normal and Streptozotocin-induced diabetic rats up to 12 h. Glibenclamide was used as a standard drug at a dose of 0.25 mg/kg (Sharma et al., 2010).