Molecular & Cellular Proteomics
ResearchIdentification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma*[S]
Graphical Abstract
Highlights
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The plasma-soluble HLA peptidome of Glioblastoma contains many tumor antigens.
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This sHLA peptidome may serve as a rich source for disease biomarkers.
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The sHLA peptidomes are highly correlated with the tumor's membranal HLA peptidomes.
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The HLA peptidomes differ significantly from the proteomes of the tumors.
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Author contributions: B.S., E.B., N.H., S. Kuttruff, C.S., C.B., J.C., S. Kreiter, K.F., P.-Y.D., W.W., M.P., U.L., C.O., S.H.v.d.B., P.T.S., B.P., H.O., H.G.R., U.S., H.S., and A.A. designed research; B.S., E.B., D.M.K., Y.H., G.S., and A.A. performed research; B.S., D.M.K., and A.A. analyzed data; B.S., E.B., N.H., C.O., and A.A. wrote the paper; G.S., I.R., C.L.-L., M.T., G.T., P.-Y.D., V.D., W.W., M.P., F.W., A.V.D., J.K., J.S., F.M.-R., J.R., C.O., S.H.v.d.B., H.S.P., U.L., and P.T.S. provide samples for analysis.
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The GAPVAC project was funded by the European Union Framework 7 Program. Funding to Carlos López-Larrea were from the European Union Fondos Feder and Instituto de Salud Carlos III (Spain, grant number PI16/01318).
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This article contains supplemental material.
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Current address: Agenus Inc., Lexington, MA.