Molecular & Cellular Proteomics
ResearchRegulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study*
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Author contributions: A.R.S., T.R.P., M.G.T., C.H., J.K.H., N.A.H., and D.L.C. designed research; A.R.S., T.R.P., and D.L.C. performed research; A.R.S., T.R.P., A.J.C., J.K.H., N.A.H., and D.L.C. analyzed data; T.R.P., A.J.C., M.G.T., J.K.H., N.A.H., and D.L.C. wrote the paper.
DLC and NAH are joint senior authors.
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ARS is supported by a scholarship from the Higher Committee for Education Development in Iraq (HCED) (D11000650). TRP is supported by the Marie Skłodowska-Curie Fellowship program. AJC is funded by EPSRC (EP/L023490/1).
This article contains supplemental Figs. S1 to S3 and Tables S1 to S5.
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The abbreviations used are:
- LAR
leukocyte common antigen-related protein
- PDGF
platelet derived growth factor
- RPTP
receptor protein tyrosine phosphatase
- SILAC
stable isotope labelling with amino acids in cell culture
- WCL
whole cell lysate
- WT
wild-type.
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Current address: Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada.