Journal of Biological Chemistry
Gene RegulationEstrogen receptor α (ERα)-binding super-enhancers drive key mediators that control uterine estrogen responses in mice
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Author contributions—S. C. H. and F. J. D. conceptualization; S. C. H. and S. A. G. formal analysis; S. C. H. and S.-P. W. validation; S. C. H., S.-P. W., and F. J. D. investigation; S. C. H. and S. A. G. visualization; S. C. H. and S. A. G. methodology; S. C. H. writing-original draft; S. C. H., S. A. G., S.-P. W., and K. S. K. writing-review and editing; S. A. G. data curation; F. J. D. and K. S. K. resources; K. S. K. funding acquisition; K. S. K. project administration.
Funding and additional information—This work was supported in part by the Intramural Research Program of NIEHS, National Institutes of Health, Grants 1ZIAES070065 (to K. S. K.) and 1ZIAES103311 (to F. J. D.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- ERα
estrogen receptor α
- KO
knockout
- ovexed
ovariectomized
- V
vehicle
- SE
super-enhancer
- TE
typical enhancer
- H3K4Me1
histone H3 Lys-4 monomethylation
- H3K27Ac
histone H3 Lys-27 acetylation
- E2
estradiol
- P4
progesterone
- LIF
leukemia-inhibitory factor interleukin-6 family cytokine
- FDR
false discovery rate
- DEG
differentially expressed genes
- RA
retinoic acid
- RAR
retinoic acid receptor
- SMRT
silencing mediator of retinoic acid and thyroid hormone receptor.