Journal of Biological Chemistry
Signal TransductionMelanocortin type 4 receptor–mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats
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This work was supported by National Natural Science Foundation of China Grants 81873731, 81771187, 81622014, 81671080, 81571063, and 81371229; the Innovation Project of Jiangsu Province Qing-Lan Project (to J. T.); Six Talent Peaks Project of Jiangsu Province Grant JY-065; Jiangsu Key Laboratory of Neuropsychiatric Diseases Grant BM2013003; and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. The authors declare that they have no conflicts of interest with the contents of this article.
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Both authors contributed equally to this work.
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The abbreviations used are:
- α-MSH
α-melanocyte–stimulating hormone
- MC4R
melanocortin type 4 receptor
- TG
trigeminal ganglion
- Kv
voltage-gated K+ channel(s)
- IA
transient outward K+ channel current(s)
- IDR
sustained delayed-rectifier K+ channel current(s)
- PI3K
phosphatidylinositol 3-kinase
- PKA
protein kinase A
- MAPK
mitogen-activated protein kinase
- CGRP
calcitonin gene–related peptide
- 4-AP
4-aminopyridine
- POMC
proopiomelanocortin
- CCI
chronic constriction injury
- CTX
cholera toxin
- PTX
pertussis toxin
- NC
negative control
- AP
action potential
- ERK
extracellular signal–regulated kinase
- JNK
c-Jun N-terminal kinase
- SAPK
stress-activated protein kinase
- GAPDH
glyceraldehyde-3-phosphate dehydrogenase
- ANOVA
analysis of variance.