Journal of Biological Chemistry
Editors' PicksEvolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity
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This work was supported in part by National Institutes of Health Grants GM111926 (to W. F., R. A. B., M. W. C., D. L. T., and R. P.), R01AI100560 (to R. A. B.), R01AI063517 (to R. A. B.), and R01AI072219 (to R. A. B.) from NIGMS and NIAID, National Science Foundation Grant CHE-1509285 (to M. W. C. and D. L. T.), Robert A. Welch Foundation Award F-1572 (to W. F.), Miami University through the Robert H. and Nancy J. Blayney Professorship (to R. C. P.), funds and/or facilities provided by the Cleveland Department of Veterans Affairs Award 1I01BX001974 (to R. A. B.), the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development, and the Geriatric Research Education and Clinical Center VISN 10 (to R. A. B.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This article was selected as one of our Editors' Picks.
This article contains Figs. S1–S10, Tables S1–S5, and supporting Refs. 1–6.
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Both authors contributed equally to this work.
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The abbreviations used are:
- NDM
New Delhi metallo-β-lactamase
- ITC
isothermal titration calorimetry
- MIC
minimum inhibitory concentration
- TEV
tobacco etch virus
- VIM
Verona integrin-borne metallo-β-lactamase
- IMP
imipenemase
- DSF
differential scanning fluorimetry
- MBL
metallo-β-lactamase.