Journal of Biological Chemistry
Volume 292, Issue 34, August 2017, Pages 14092-14107
NeurobiologyPhosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules
Under a Creative Commons license
open access
confocal microscopy
dopamine
Parkinson disease
phosphorylation
vesicles
axonal transport
tyrosine hydroxylase phosphorylated at Ser-31
tyrosine hydroxylase
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This work was supported by Research Council of Norway Grant FRIMEDBIO 214012 and the K. G. Jebsen Foundation. The authors declare that they have no conflicts of interest with the contents of this article.
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The abbreviations used are: PD, Parkinson's disease; l-DOPA, l-3,4-dihydroxyphenylalanine; GC, Golgi complex; TH, tyrosine hydroxylase; DA, dopamine; VMAT2, vesicular monoamine transporter 2; NGF, neuronal growth factor; α-syn, α-synuclein; R/S, roscovitine and SL327; sytI, synaptotagmin I; PLA, proximity ligation assay; WGA, wheat germ agglutinin; CVM, chromaffin vesicle membrane.
© 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.