Journal of Biological Chemistry
Volume 291, Issue 35, 26 August 2016, Pages 18591-18599
Journal home page for Journal of Biological Chemistry

Accelerated Communications
NHX-5, an Endosomal Na+/H+ Exchanger, Is Associated with Metformin Action*

https://doi.org/10.1074/jbc.C116.744037Get rights and content
Under a Creative Commons license
open access

Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na+/H+ exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.

autophagy
Caenorhabditis elegans (C. elegans)
drug action
endosome
metformin
sodium-proton exchange
Type 2 diabetes

Cited by (0)

*

This work was supported by Inha University (to J. K.), Korean MEST Grant 2012R1A1A2041099 (to K. J. M.), Virginia Commonwealth University School of Medicine (to Y. J. Y.), and Nagoya Research Center for Brain & Neural Circuits (to Y. J. Y.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.