Journal of Biological Chemistry
Accelerated CommunicationsHeterogeneous adaptation of cysteine reactivity to a covalent oncometabolite
Cited by (0)
This article contains supporting information.
Author contributions—M. P., D. W. B., S. E. B., E. W., and J. L. M. conceptualization; M. P., D. W. B., E. W., W. M. L., and J. L. M. data curation; M. P., D. W. B., D. R. C., E. W., W. M. L., and J. L. M. formal analysis; M. P., D. W. B., S. E. B., E. W., W. M. L., and J. L. M. investigation; M. P., D. W. B., S. E. B., D. R. C., B. S. A., Y. Y., E. W., W. M. L., and J. L. M. methodology; M. P., D. W. B., and J. L. M. writing-original draft; M. P., D. W. B., D. R. C., E. W., W. M. L., and J. L. M. writing-review and editing.
Funding and additional information—This work was supported by the Intramural Research Program of the NCI, National Institutes of Health, Center for Cancer Research (ZIA BC011488 and ZIA BC011038) and the CCR FLEX Program. Support for E. W. was provided by National Institutes of Health Grants 1R01GM117004 and 1R01GM118431-01A1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- HLRCC
hereditary leiomyomatosis and renal cell carcinoma
- TCA
tricarboxylic acid
- FH
fumarate hydratase
- IA-alkyne
iodoacetamide alkyne
- ReDiMe
reductive dimethyl
- AMPK
5'-AMP-activated protein kinase
- MHC
major histocompatibility complex
- SICyLIA
stable isotope cysteine labeling with iodoacetamide.