CELL BIOLOGY AND METABOLISM
Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion*

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The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with β-catenin. Similar findings have been obtained for γ-catenin but not α-catenin. DF3, like E-cadherin and the adenomatous polyposis coli gene product, contains an SXXXXXSSL site that is responsible for direct binding to β-catenin. The results further demonstrate that interaction of DF3 and β-catenin is dependent on cell adhesion. These findings and the role of β-catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells.

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This work was supported by Department of the Army Grant DAMD 17-94-J-4394.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

© 1997 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.