Molecular & Cellular Proteomics
ResearchIntegrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male Fertility*[S]
Graphical Abstract
Highlights
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CMTM4 is associated with human spermatogenesis and sperm quality.
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Cmtm4 knockout mouse were generated by CRISPR/Cas9 technology for male fertility research.
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CMTM4 is required for male fertility but not female fertility.
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Phenotype and quantitative proteomics of Cmtm4 KO mice reveal an association of CMTM4 with histone-to-protamine exchange, sperm motility and induction of the acrosome reaction.
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The authors declare no conflict of interest.
Author contributions: F.L. and W.H. designed research; F.L., X.-X.L., X.L., P.Z., H.X., and W.W. performed research; F.L., X.-X.L., X.L., T.L., P.Z., Z.L., W.W., X.Y., and J.L. analyzed data; F.L. and W.H. wrote the paper; X.-X.L., X.L., T.L., P.Z., Z.L., H.X., W.W., X.Y., and J.L. contributed new reagents/analytic tools.
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The current study was supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2018PT31039), National Natural Science Foundation of China (81571490), Shandong Provincial Natural Science Foundation, China (grant no. ZR2014HQ068).
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This article contains supplemental material.