Journal of Biological Chemistry
Molecular Bases of DiseaseFull-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
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This work was supported in whole or part by National Institutes of Health Predoctoral Training Grant T32 GM008666; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Grant 2013/18028-9, and National Institutes of Health Grants RF1 AG048083-01 and 2P50 AG005131-31 from NIA. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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The abbreviations used are:
- AD
Alzheimer's disease
- APP
amyloid precursor protein
- CTF
C-terminal fragment
- Aβ
amyloid-β
- KO
knockout
- hiPSC
human induced pluripotent stem cell
- iPSC
induced pluripotent stem cells
- LDL
low density lipoprotein
- LDLR
low density lipoprotein receptor
- SREBP
sterol-regulatory element-binding protein
- BBR
berberine
- SREBP
sterol regulatory element-binding protein
- qRT-PCR
quantitative RT-PCR
- NPC
neural precursor cell
- HMGCR
HMG-CoA reductase
- sAPP
soluble APP
- FL
full length
- Tfn
transferrin
- SAD
sporadic Alzheimer's disease
- FAD
familial Alzheimer's disease
- BSI
β-secretase inhibitor
- DMEM
Dulbecco's modified Eagle's medium
- RI
ROCK inhibitor
- FBS
fetal bovine serum
- BisTris
2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
- MEF
mouse embryonic fibroblast.