Journal of Biological Chemistry
Protein Synthesis, Post-Translational Modification, and DegradationThe Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins*
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The abbreviations used are: UPS, ubiquitin proteasome system; CHIP, C terminus of Hsp70-interacting protein; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; HECT, homologous to E6-AP C terminus; ER, endoplasmic reticulum; CFTR, cystic fibrosis transmembrane conductance regulator; MTOC, microtubule-organizing center; HD, Huntington disease; GFP, green fluorescence protein; E1, ubiquitin-activating enzyme; E2, ubiquitin carrier protein; E3, ubiquitin-protein isopeptide ligase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.
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This work was supported by the Department of Biotechnology, Government of India.
The on-line version of this article (available at http://www.jbc.org) contains supplemental Figs. S1 and S2.
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Supported by research fellowship from Council of Scientific and Industrial Research, Government of India.