Journal of Biological Chemistry
DNA and ChromosomesThe Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity*RecQ4 Helicase Contains a Functional RQC Domain
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This work was supported by Associazione Italiana per la Ricerca sul Cancro Grants IG10646 and IG14718, the ICTP TRIL Fellowship programme, the Cross-Border Cooperation Programme Italy-Slovenia 2007–2013 by the European Regional Development Fund and national funds (PROTEO), and the European Community's Seventh Framework Programme (2007–2013) under BioStruct-X Grant Agreement 283570. The authors declare that they have no conflicts of interest with the contents of this article.
This article contains supplemental Figs. S1–S3.
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The abbreviations used are:
- RQC
RecQ C-terminal domain
- WH
winged helix
- SAXS
small angle X-ray scattering
- ICP-AES
inductively coupled plasma-atomic emission spectrometry
- ssDNA
single-stranded DNA
- MG
malachite green
- 6-FAM
6-carboxyfluorescein
- PDB
Protein Data Bank
- HR
helicase-RQC
- HRD
human RecQ4-DNA complex.