Journal of Biological Chemistry
Molecular Bases of DiseaseDown-regulation of the Antisense Mitochondrial Non-coding RNAs (ncRNAs) Is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy*
Cited by (0)
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This work was supported by Comisión Nacional de Ciencia y Tecnología (Conicyt), Chile (Fondo Nacional de Ciencia y Tecnologia (Fondecyt) 1110835 and 1140345 (to V. A. B.), Fondecyt 11090060 (to C. V.), Fondecyt 1085210 (to J. V.), Fondef-D04I1338 (to J. V.), and CCTE-PFB16), and Universidad Andrés Bello, Chile (DI-34-09/R, DI-31-09/R, DI-28-09/R4, and DI-06-09/R).
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L. Lobos-González, V. Silva, S. Vidaurre, J. Echenique, M. Araya, M. Varas, L. Oliveira-Cruz, C. Fitzpatrick, F. Restovic, C. Villota, J. E. Villegas, C. López, T. Socías, L. O. Burzio, and V. A. Burzio, unpublished results.
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Both authors contributed equally to the work.
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The abbreviations used are:
- ncRNA
non-coding RNA
- ncmtRNA
non-coding mitochondrial RNA
- SncmtRNA
sense ncmtRNA
- ASncmtRNA
antisense ncmtRNA
- AS-1
ASncmtRNA-1
- AS-2
ASncmtRNA-2
- IAP
inhibitor of apoptosis protein
- ASK
ASncmtRNA knockdown
- ASO
antisense oligodeoxynucleotide
- ASO-C
control ASO
- miR
microRNA
- PI
propidium iodide
- PNA
peptide nucleic acid
- PS
phosphorothioate
- CCCP
carbonyl cyanide 3-chlorophenylhydrazone
- ΔΨm
mitochondrial membrane potential
- IP
immunoprecipitate
- STP
staurosporine
- Tb
trypan blue
- EdU
5-ethynyl-2′-deoxyuridine
- XIAP
X-linked inhibitor of apoptosis protein
- HPV
human papilloma virus
- HFK
human foreskin keratinocyte
- HnEM
human normal epidermal melanocyte
- HREC
human normal renal epithelial cells
- HUVEC
human umbilical vein endothelial cells
- RT
room temperature
- FISH
fluorescence in situ hybridization
- TEM
transmission electron microscopy
- NT
not treated
- z-VAD-fmk
benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone.