Journal of Biological Chemistry
Volume 285, Issue 43, 22 October 2010, Pages 32695-32703
EnzymologySIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
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Under a Creative Commons license
open access
Allosteric Regulation
Drug Design
Enzyme Kinetics
Enzyme Mechanisms
Sirtuins
Enzyme Activation
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Ten authors, with the exception of B. P. H., are employed by Sirtris, a GSK Company, which has a commercial interest in developing SIRT1 activators.
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The on-line version of this article (available at http://www.jbc.org) contains supplemental experimental procedures and characterization data and Figs. S1 and S2.
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This article was selected as a Paper of the Week.
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Both authors contributed equally to this work.
© 2010 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.