Journal of Biological Chemistry
Protein Structure and FoldingProenzyme Structure and Activation of Astacin Metallopeptidase*
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This paper is dedicated to Wolfram Bode on the occasion of his 68th birthday and to acknowledge his groundbreaking contributions to the structural analysis of metallopeptidases.
The atomic coordinates and structure factors (code 3LQ0) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
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This work was supported by grants from European, Spanish, and Catalan public agencies (Strep FP7-223101-AntiPathoGN, BIO2008-04080-E, BIO2009-10334, CSD2006-00015, PSE-010000-2009-8, and 2009SGR1036) and by Deutsche Forschungsgemeinschaft Grant Sto185/3-3. Funding for data collection was provided by the European Synchrotron Radiation Facility.
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Present address: The Overall Laboratory, Centre for Blood Research, University of British Columbia; Rm. 4.401, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.