Synthesis of haptens related to (Z)- and (E)-clomiphene

Abstract

Syntheses of (Z)- and (E)-3-[4-(2-chloro-1,2- diphenylvinyl)phenoxy]propanoic acids (12) and (11),potential haptens for the individual quantitation of the Z and of the E isomers of clomiphene,2-[4-(2-chloro-1,2-diphenylvinyl)phenoxy]-N,N- diethylethanamine (2) and (1), by radioimmunoassay, are described.