Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and Maxillofacial PathologyCollagenous fibroma (desmoplastic fibroblastoma) of the palate: A case report*
Section snippets
Case report
A 37-year-old white woman was referred to the Oral and Maxillofacial Surgery Clinic at Vila Penteado Hospital, São Paulo, in August 1999, for evaluation of a firm swelling on the left soft and hard palate that had appeared spontaneously and had been growing slowly for almost 18 months. The patient was otherwise in good health, and her medical history was not contributory. Intraoral examination showed a 5.0-cm painless, solitary, firm, well-circumscribed nodule, covered by normal mucosa (Fig 1).
Discussion
The clinicopathologic features of the case described in this article met the criteria for the diagnosis of CF reported by Evans1 and Nielson et al,2 who defined desmoplastic fibroblastoma and collagenous fibroma, respectively. Clinically, the tumor presented as a solitary, firm, well-circumscribed, painless, large mass of long duration (18 months). On gross examination, the lesion appeared as an oval mass with a resilient, fibroelastic consistency and a homogeneous fibrous cut surface.
Acknowledgements
We thank Edna Toddai and Elisa dos Santos (Oral Pathology Laboratory, School of Dentistry, University of São Paulo) for technical expertise and assistance, and Dr Shajadi Carlos Pardo Kaba and Dr Fernando Melhem Elias (São Paulo Vila Penteado Hospital) for assistance in surgery.
References (11)
- et al.
Collagenous fibroma (desmoplastic fibroblastoma): a clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts
Hum Pathol
(1998) - et al.
Collagenous fibroma (desmoplastic fibroblastoma)
J Am Acad Dermatol
(1999) Desmoplastic fibroblastoma. A report of seven cases
Am J Surg Pathol
(1995)- et al.
Collagenous fibroma (desmoplastic fibroblastoma): a report of seven cases
Mod Pathol
(1996) - et al.
Collagenous fibroma (desmoplastic fibroblastoma). Report of four cases and review of the literature
Arch Pathol Lab Med
(1998)
Cited by (40)
A case of a massive desmoplastic fibroblastoma on the mandibular gingiva
2023, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCitation Excerpt :DF may occur in various areas of the body, and 10 cases of intraoral DF have been reported from 2001 to 2018 to our knowledge. Table 1 summarizes 2 cases in the buccal mucosa [13,17], 1 case in the maxillary gingiva [7], 3 cases in the hard palate [8,14,18], 2 cases in the tongue [19,20] and 2 cases in the mandibular gingiva [5,9]. Surgical excision was performed in these cases and no recurrences were reported.
Translocation t(2;11) is characteristic of collagenous fibroma (desmoplastic fibroblastoma)
2011, Cancer GeneticsCitation Excerpt :Mutations in the COL3A1 gene are associated with Ehlers-Danlos syndrome type IV (19). Interestingly, Mesquita et al. (20) reported that tumor extracellular matrix was immunopositive for type I and III collagen in a collagenous fibroma. Rearrangements of collagen gene(s) have been identified in several bone and soft-tissue tumors.
A rare tumour of the arm in a child
2009, Annales de PathologieDesmoplastic fibroblastoma of the foot. A case report
2008, Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil MoteurBilateral collagenous fibroma of the hard palate: a case report and review of the literature
2023, Journal of Medical Case ReportsLateral neck swellings: Diagnostic and therapeutic challenges
2023, Lateral Neck Swellings: Diagnostic and Therapeutic Challenges
- *
Reprint requests: Vera Cavalcanti de Araújo, DDS, PhD, Universidade de São Paulo, Faculdade de Odontologia, Disciplina de Patologia Bucal, Av Prof Lineu Prestes 2227, Cidade Universitária, São Paulo-SP, Brazil