General Obstetrics and Gynecology: ObstetricsPregnancy outcome of female survivors of childhood cancer: A report from the childhood cancer survivor study☆,☆☆,★
Section snippets
Patients and methods
A cohort of 20,319 previously untreated patients who were <21 years old at diagnosis and who were diagnosed with an eligible cancer between January 1, 1970, and December 31, 1986, was identified at the 25 participating institutions of the Childhood Cancer Survivor Study (CCSS). The study design and cohort characteristics are presented in detail elsewhere.11 Briefly, all members of the cohort, or a proxy, if the cohort member was deceased, completed a baseline questionnaire that included items
Results
Six thousand four hundred ninety-four women returned a baseline questionnaire. One thousand nine hundred fifteen indicated that they had ever been pregnant and reported 4029 pregnancies. The gender ratio (male/female) was 1.09:1.0 for the offspring of the female survivors compared with 1.09:1.0 for the offspring of the female siblings of all the male and female survivors.
Comment
The survival rate of pediatric cancer patients has improved dramatically during the past two decades,1 with many former patients now achieving young adulthood and beginning to make decisions regarding marriage and reproduction. Because radiation therapy and many of the chemotherapeutic agents that are used alone or as a component of successful treatment programs for a variety of cancers in children and adolescents are mutagenic, these long-term survivors are concerned about the potential effect
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Supported by National Cancer Institute grant No. U24 CA55727 from the National Institutes of health. Support was provided to the University of Minnesota Cancer Center from the Children's Cancer Research Fund.
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An abstract of this paper was published in Med Pediatr Oncol 1999;33:146.
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Reprint requests: Daniel M. Green, MD, Department of Pediatrics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. E-mail: [email protected]