Antithyroid antibodies in chronic urticaria and angioedema
Section snippets
To the Editor:
Chronic urticaria (CU) was a cutaneous disease of unknown origin until the past decade, during which a subpopulation comprising approximately 35% to 45% of patients was found to show evidence of an autoimmune disorder. At least 35% of patients with CU have an IgG antibody directed to the α subunit of the IgE receptor,1, 2 whereas an additional 5% to 10% of patients have anti-IgE that is functional.3 These antibodies cross-link the IgE receptor to cause mast cell degranulation. Fixation of
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Cited by (105)
The Diagnostic Workup in Chronic Spontaneous Urticaria—What to Test and Why
2021, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :It is therefore advisable to assess patients with CSU for CSUaiTI and CSUaiTIIb. Differentiating factors include time since the onset of disease (longer in CSUaiTIIb)1,2 and concomitant autoimmune diseases (more common in CSUaiTIIb).13,15,18-20 Also, results of basic CSU tests (ie, CBC with differential, CRP) can differentiate between type I versus type IIb autoimmune CSU, with CRP more often elevated and eosinophil and basophil levels more often reduced in the latter than the former.21
Detection of circulating IgG autoantibody to FcεRIα in sera from chronic spontaneous urticaria patients
2020, Journal of Microbiology, Immunology and InfectionCitation Excerpt :The remaining 7 in the negative IgG to FceR1α group were still unresponsive or partly responsive to anti-IgE treatment. Studies have indicated that 30–60% of patients with CSU has an autoimmune etiology on the basis of various laboratory and clinical evidence.2–7,10,13,15–17 The prevalence of thyroid autoimmunity in patients with CU was previously reported as 12–30%.16,17
Autoimmune chronic spontaneous urticaria: What we know and what we do not know
2017, Journal of Allergy and Clinical ImmunologyHistaminergic angioedema and chronic urticaria
2015, Presse MedicaleChronic Spontaneous Urticaria: The Devil's Itch
2018, Journal of Allergy and Clinical Immunology: In Practice